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Retin-A and Retin-A Micro Are The Same Product But Formulated Differently Retin-A and Retin-A Micro are basically different versions of the same medication. They work in the same way, they're used to treat the same skin problems, and they contain the same active ingredient Tretinoin. The main difference between Retin-A Micro and Retin-A is how they are formulated. Retin-A Micro only comes in gel form. The "micro" in the name stands for microsphere. That's where Retin-A Micro has an edge on Retin-A. These microspheres release the medication more slowly, over time. Hence they are less irritating and are good in antiaging. They also help get rid of fine lines and wrinkles.